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Patrick Dempsey has only one rule for his legions of female fans: don’t touch the hair.

The “Grey’s Anatomy” star told “Extra” that his adoring fans have an odd tendency to try to run their fingers through his mane.

“You politely take their hand away from your head and you slap it,” Patrick joked. “No, no, it is always fun.”

So how does his wife Jill handle all that attention?

“Very well, much better than I would,” he admits. “She’s a saint.”

Patrick also gave “Extra” an update on his nine-month-old twin boys, saying, “They are great! They are waving good-bye and saying ‘mom’ and ‘dad.’”