A dreadful tale of domestic violence, Koi Mere Dil Se Pooche is the story of Eisha an innocent girl who is married off to Dushyant, an eccentric landlord. On their honeymoon, Dushyant lets his friends molest Eisha and captures it on camera. Eisha makes a daring escape and sets the tent on fire killing Dushyant. When Eisha's mother-in-law Mansi Devi arranges for Eisha's second marriage, Dushyant reappears and threatens to wreck the marriage. Will Eisha be able to lead a happy life ever?