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gastrointestinal, prostate, hepatobillary hepatocellular carcinoma, pancreatic cancer , ovarian, hematologic or lung malignancies. AIDS can cause weight loss and should be suspected in high-risk individuals presenting with weight loss. Gastrointestinal disorders are another common cause of unexplained weight loss - in fact they are the most common non-cancerous cause of idiopathic weight loss. Possible gastrointestinal etiologies of unexplained weight loss are celiac disease , peptic ulcer , inflammatory bowel disease crohns disease and ulcerative colitis , pancreatitis , gastritis, diarrhea and many other GI conditions can cause weight loss. Infection Some infectious diseases can cause weight loss. AIDS , and some other sub-acute or occult infections may cause weight loss. Cardiac disease Cardiovascular disease, especially congestive heart failure, may cause unexplained weight loss. In some people, certain medications may cause