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    The Elephant Man movie trailer WWW.GOODNEWS.WS

    436 visualizzazioni This is the trailer from the beautiful movie "The Elephant Man", starring Anthony Hopkins, John Hurt and Anne Bancroft. The movie is based on the true life of John (Joseph) Merrick who lived from 1862 to 1890 and suffered from The Protheus Syndrome. - 'Elephant Man' Gene Mutation Identified. NIH researchers identify gene variant in Proteus syndrome. Molecular insight may confirm cause of the Elephant Man's severe disfigurement. A team of researchers has identified the genetic mutation that causes Proteus syndrome, a rare disorder in which tissue and bone grows massively out of proportion. The discovery, which has implications for potential drug therapies and even cancer, appears in the July 27, 2011, early online edition of the New England Journal of Medicine. The team was led by researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health. Proteus syndrome gained wide public attention in 1980, through the movie "The Elephant Man," about a 19th century Londoner whom experts believe may have suffered from the disease.Researchers found that a point mutation — a single-letter misspelling in the DNA of the genetic code — in the AKT1 gene activates the sporadic tissue growth characteristic of Proteus syndrome. Physicians named the condition for the Greek god who could transform his shape. There are fewer than 500 people with the disease in the developed world, where it can be tracked.Unlike inherited disease-causing mutations, the gene variant that triggers Proteus occurs spontaneously in each affected individual during embryonic development. The severity of the disease depends on the timing during embryonic development that the genetic mistake occurs in a single cell and in which part of the developing organism. Only the cells that descend from the cell with the original AKT1 gene mutation display the hallmarks of the disease, leaving the individual with a mixture of normal and mutated cells.The affected newborn appears normal, but symptoms arise in the child's first two years. The mutation in AKT1 alters the ability of affected cells to regulate their own growth, leading some parts of the patient's body to grow to abnormal and even enormous sizes, while other parts of the body remain normal. The irregular overgrowth worsens with age and increases the susceptibility to tumors."This study resolves a daunting challenge in clinical genetics and offers hope for patients with Proteus syndrome," said NHGRI Director Eric D. Green, M.D., Ph.D. "This rare disorder has been the focus of curiosity and medical observation for decades but until now has never been biologically explained. With the analysis reported here, patients and families who face this condition have hope for future therapies." As follow up to the current study, NHGRI researchers plan to test DNA from the skeleton of Joseph Merrick to determine whether Proteus syndrome caused his dramatic disfigurement. Merrick gained celebrity — and for a time earned his livelihood in England and Europe — by being displayed in human novelty exhibitions as the Elephant Man. He died in 1890 at the age of 27 in London Hospital, now the Royal London Hospital, where he resided at the end of his life. The hospital preserved his skeleton in its pathology collection, providing modern researchers a chance to test his century-old DNA. Merrick's life has been portrayed on stage, and in a 1980 Hollywood movie titled "The Elephant Man." Diagnosing Merrick will be no simple study. Read the full story » The Elephant Man movie trailer WWW.GOODNEWS.WS