A girl child is born to a helpless mother when the jatara (a public religious festival) of Goddess Mysamma is going on in a Telangana village. The child is named as Mysamma. Her parents are killed in a natural calamity. The child is taken care of by her sister Durga. A small time rowdy Sadhu (Sayaji Shinde) marries Durga & forces her to do prostitution for his political ambitions. At one stage, the rowdy tries to rape minor girl Mysamma. While both sister run for their life, Sadhu prompts his dogs to kill his wife Durga, while Mysamma escapes. She later becomes a Police officer Mysamma IPS. She lives for one goal -- to kill those wh is responsible for her sister's miserable life followed by her death.