Neil Patrick Harris, Jayma Mays, Sofia Vergara, and Hank Azaria star on camera opposite an all-star voice cast. Anton Yelchin will play Clumsy Smurf; comedy legend Jonathan Winters, who voiced roles in the "Smurfs" television series, will voice Papa Smurf; Grammy-nominated singer-songwriter Katy Perry will play Smurfette; Alan Cumming will play Gutsy Smurf; "SNL's" Fred Armisen will voice Brainy Smurf; and George Lopez will play Grouchy Smurf.
In the live-action roles, Azaria will play the Smurfs' nemesis, the evil wizard Gargamel. Harris and Mays star as an expectant couple whose lives are turned upside down when the Smurfs cross over from their magical village to New York City. Vergara plays Odile, Harris's boss, a cosmetics executive.