Arsenal vs Manchester United
For so long this looked to be a potential title decider but Arsene Wenger now accepts his side's challenge is over after a run of just one win in six.
By contrast, United have taken 13 points from a possible 15 and if they win at the Emirates it will mathematically put them out of reach of the Gunners.
Arsenal have drawn their last three home fixtures and have already lost twice to the Red Devils at Old Trafford this season, going down 1-0 in the Barclays Premier League and 2-0 in the FA Cup.
United won last season's corresponding fixture 3-1 and victory again would all but ensure the title.