Arsenal face a stiff task in the last 16 of the Champions League after they were drawn against Spanish champions Barcelona.
Pep Guardiola's team eliminated Arsenal in the quarter-finals last season thanks to a virtuoso display by Lionel Messi and are the bookmakers' favourites again following last month's 5-0 thrashing of Real Madrid.
Tottenham, top scorers in the group stage, also face a tough task against AC Milan, in their first experience of the knockout stages of the Champions League.
Milan are currently six points clear at the top of Serie A and with plenty of Champions League experience in their ranks.
Chelsea were given arguably the easiest draw of the round, up against Danish champions FC Copenhagen, while Manchester United will play Marseille.
The other ties see Lyon take on Jose Mourinho's Real Madrid, holders Inter, now managed by Rafa Benitez, will face Bayern Munich, Valencia will play Schalke and Roma have to overcome Shakhtar Donetsk.