A vampiric virus is spreading across the country. Amid the chaos, Eph Goodweather -- head of the Center for Disease Control's team and the leader of a small group who has banded together to fight these bloodthirsty monsters -- has finally identified the parasite causing the infection. But it may be too late. Ignited by the Master's horrific plan, a war erupts between Old and New World vampires, each vying for total control. Caught between these warring forces, humans -- powerless, vulnerable -- are no longer the consumers, but the consumed.