AFTER your WP installation, this plugin http://www.seoautomatic.com/plugins/wp-core-tweaks/
will save you AT LEAST 20 minutes, no matter how well you know WordPress, and no matter what you want to change.
Newbies can use the defaults, while experts will find all of the time consuming steps for proper setup placed in one simple admin panel with a one -click process. Even the error messages have been made user friendly!
If you set up WordPress sites on a regular basis, or you're just looking to do it once, you've got to see this...