Saying goodbye is always hard. Especially when it comes to TV characters that we cherish. ABC’s medical drama Grey’s Anatomy has created many of these emotional moments over the years. Here are the top five most shocking cast departures from Grey’s Anatomy!

Grey's Anatomy Cast:

Ellen Pompeo, Chandra Wilson, James Pickens, Jr., Kevin McKidd, Caterina Scorsone, Camilla Luddington, Kelly McCreary, Kim Raver, Jake Borelli, Chris Carmack, Richard Flood, Anthony Hill and Scott Speedman

Stream Grey's Anatomy now on ABC!