"Just Stand Up!" is a song featuring the vocals of an all-star group of pop/R&B/rock performers, including Mariah Carey, Beyoncé, Mary J. Blige, Rihanna, Fergie, Sheryl Crow, Melissa Etheridge, Natasha Bedingfield, Miley Cyrus, Leona Lewis, Carrie Underwood, Keyshia Cole, LeAnn Rimes, Ashanti and Ciara. American songwriter and producer Antonio "L.A." Reid conceived the collaboration after a meeting with the founder of Stand Up to Cancer, which will benefit from the proceeds of the record. Reid co-produced the track with American singer Kenneth "Babyface" Edmonds, and the single was released on August 29, 2008.
The singers performed "Just Stand Up!" live on the "Stand Up to Cancer" telethon which aired simultaneously on ABC, CBS and NBC on September 5.