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In the "Pilot," we're introduced to John Amsterdam - a brilliant New York homicide detective who's also an immortal being. John will only start aging once he finds his true love which hasn't happened for the past 400 years of his life. John's homicide partner is a woman named Eva Marquez. The only person who knows John's secret of immortality is Omar, who also happens to have his own secret safe with John.
John escapes death when he finds himself investigating the murder of a socialite who is somehow connected to his past.