Reham Khan was born to Dr. Nayyar Ramzan, a physician. She is an ethnic Pashtun, belonging to Lughmani clan of Swati tribe, and hails from the Baffa village in Mansehra, Khyber Pakhtunkhwa. Reham Khan parents moved to Libya in the late 1960s, where Reham Khan was born in Ajdabiya in 1973. She has two sisters and a brother.

Reham Khan did her Bachelor Degree in Education and started a Postgraduate in Sociology but due to a change in her personal circumstances. Reham Khan switched to a Postgraduate in Broadcast Journalism at North Lindsey College, United Kingdom. Reham Khan married Ejaz Rehman, her first cousin and British psychiatrist, when she was 19.


On 6 January 2015 after months of speculation, Imran Khan confirmed marriage with Reham.
Reham Khan started her career as weather forcaster in BBC, she also held the position as a broadcast journalist on BBC South. Later in 2006, she joined Legal TV. In 2007, Reham began presenting for Sunshine Radio Hereford and Worcester. In 2008, Khan joined BBC as broadcast journalist.

In 2013, Reham Khan came to Pakistan and joined Pakistani news channel News One. She later joined AAJ TV.

Now again Reham khan married with Imran Khan After divorce .