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Lisa Edelstein (/ˈliːsə ˈɛdəlstiːn/; born May 21, 1966) is an American actress and playwright best known for playing Dr. Lisa Cuddy on the medical drama series House MD.
Edelstein was born in Boston, Massachusetts, the daughter of Bonnie and Alvin Edelstein. Her father is a pediatrician at Chilton Memorial Hospital (since retired). Her family is Jewish.The youngest of three children, she was raised in Wayne, New Jersey, and attended Wayne Valley High School, graduating in 1984.
After being dubbed a "celebutante" by The New York Times magazine during her club kid days Edelstein used her new-found celebrity to write, compose, and star in an original musical called Positive Me in response to the growing AIDS crisis of the 1980s. After a brief stint hosting Awake on the Wild Side for MTV in 1990, she spent the early 1990s appearing in guest roles on several popular comedies, including Mad About You, Wings, and The Larry Sanders Show. On Sports Night, she played a sports reporter who claimed to be a former lover of Josh Charles's character whom he did not remember. On Seinfeld, she played George Costanza's frustrated girlfriend, the "Risotto Girl" (the only girlfriend of George's to appear in multiple episodes other than Susan Ross).
Edelstein picketed during the 2007--08 Writers Guild of America strike, which halted the production of House.
Bigger roles in TV dramas soon followed, among them the lesbian sister on ABC's Relativity (1996); a high-priced call girl turned Rob Lowe's date on The West Wing (1999); an assigned male at birth (AMAB) transgender woman on Ally McBeal (2000); and Ben Covington's (Scott Speedman) girlfriend on Felicity (2001). She also continued to land guest star spots on such shows as ER, Frasier, Just Shoot Me!, Without a Trace, and Judging Amy.
The actress has lent her voice to several animated programs including King of the Hill, American Dad!, Superman: The Animated Series (as Mercy Graves, Lex Luthor's bodyguard, a role she later reprised in several episodes of Justice League) and the video game adaptation of Blade Runner (1997). Edelstein's film credits include small parts and cameos in What Women Want, Keeping the Faith, As Good as It Gets, and Daddy Day Care.
From 2004 to 2011, she played Dr. Lisa Cuddy, the Dean of Medicine at Princeton-Plainsboro Teaching Hospital and frequent character foil and ex-girlfriend to title character Gregory House (Hugh Laurie) on Fox's TV series House, M.D. In May 2011, Edelstein announced that she would not return for the eighth season of House.