England will continue their quest to reach the 2014 World Cup in Brazil on Friday evening.
Moldova are the visitors to Wembley Stadium, who England thrashed 5-0 in the reverse fixture almost exactly a year ago.
Roy Hodgson's team are second in Group H, two points behind Montenegro and one ahead of Ukraine, who they visit on Tuesday.
Without Manchester United's Wayne Rooney due to a gashed head and Liverpool's Daniel Sturridge because of a thigh problem, England will turn to Rickie Lambert up front.
The Southampton man scored with his first international touch after coming off the bench against Scotland last month.
Hodgson's headaches haven't only been in attack - defenders Phil Jones and Glen Johnson have also withdrawn from the 'Three Lions' squad - but England should still claim a win.