The San Francisco 49ers will travel to the Midwest to battle the Kansas City Chiefs in a week two NFL preseason game scheduled for Friday night.

Kick off time from Kansas City is set for 8PM Eastern Time with live television coverage available only in the San Francisco and Kansas City markets.

The odds from this NFL week two preseason game have the road side San Francisco 49ers favored by -1 points with an over under line set at 38 ½ points. Those who wager on San Francisco on the money line will lay -115 odds with the return on the home underdog Kansas City Chiefs a -105 odds to post the straight up win without needing points on their side.